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Biochem Pharmacol 77(5):858866

[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Saitoh T, Satoh H, Nobuhara M, et al

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Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1-regulated transcription

They don't go through the same rigorous safety and efficacy testing as FDA-approved drugs, which means they could increase health risks or be less effective